Denso 221-0510 Radiator

Brand Denso 221-0510
Core Height 17.6870
Core Thickness 0.6250
Core Width 29.0000
Inlet Diameter 0.9370
Outlet Diameter 0.9370
Transmission Oil Cooler Included YES
Fits Toyota · 7 vehicles

OE experience. Built with OE-level know-how for reliable performance and fit.

Radiator performance. Helps maintain proper engine cooling and function.

Transmission oil cooler included. Adds integrated cooling support in one assembly.

Cross-references APDI 8012377, CSF 2821 and CSF 3473 for the same application. See all 14.

$154.99Free shipping
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Denso Radiator for Toyota Highlander

The Denso 221-0510 radiator is built for 2001-2007 Toyota Highlander models without the tow package. It features OE-matched core dimensions, integrated transmission oil cooler support, and inlet and outlet sizes that align with factory cooling system requirements.

Key Features

  • Core height: 17.6870
  • Core width: 29.0000
  • Core thickness: 0.6250
  • Transmission oil cooler included: Yes
  • Inlet diameter: 0.9370
  • Outlet diameter: 0.9370
  • OE-focused radiator construction for factory-style fitment

Product Details

Denso 221-0510 is a replacement radiator engineered around OE specifications for the Toyota Highlander. Denso supplies radiators to vehicle manufacturers worldwide, and this unit reflects that OE experience through its core sizing, tank configuration, fin pitch, and material selection. For drivers searching for a Toyota Highlander radiator replacement, this part number 221-0510 offers the correct cooling-system layout for models without the tow package.

This part cross-references Spectra Premium CU2452 and Toyota 16400-20220 for the same application.

Common Cooling System Issues

  • Overheating caused by a restricted or leaking radiator
  • Transmission fluid temperature concerns when the cooler circuit is compromised
  • Coolant loss from cracked tanks or damaged core sections
  • Reduced heat transfer from worn internal passages or fin damage
  • Fitment problems when replacing a radiator with the wrong inlet or outlet size

Installation Notes and Tips

Fits 2001-2007 Toyota Highlander, N/A, without Tow Package. Verify inlet and outlet diameter, core dimensions, and transmission cooler line routing before installation. Flush the cooling system, inspect hoses and clamps, and confirm the radiator cap and fan operation are in good condition. Part number 221-0510 should be matched to the vehicle’s build configuration before installation.

Quality Assurance

Denso radiators are built to meet OE manufacturer standards and are tested for durability and function before release. That process helps ensure consistent cooling performance and fitment on Toyota Highlander applications.

This part fits 7 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelFuel TypePositionNotes
2007ToyotaHighlanderGASN/AFits models without Tow Package.
2006ToyotaHighlanderGASN/AFits models without Tow Package.
2005ToyotaHighlander—N/AFits models without Tow Package.
2004ToyotaHighlander—N/AFits models without Tow Package.
2003ToyotaHighlander—N/AFits models without Tow Package.
2002ToyotaHighlander—N/AFits models without Tow Package.
2001ToyotaHighlander—N/AFits models without Tow Package.
Directly replaces or cross-references 14 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012377CSF — 2821CSF — 3473DPI Performance Racing Products — 2849OSC — 2452OSC — 2848Reach Cooling — 41-2452Spectra Premium — CU2452Toyota — 16400-20220Toyota — 16400-20330Toyota — 16410-YZZALTYC Cooling - Archived — 2452TYC Cooling - Archived — 2849Vista Pro — 432448