Denso 221-0520 Radiator

Brand Denso 221-0520
Core Height 18.8120
Core Thickness 0.8750
Core Width 26.5620
Inlet Diameter 0.9370
Outlet Diameter 1.5620
Transmission Oil Cooler Included YES
Fits Toyota · 1 vehicle

OE experience. Built to meet strict OE standards for fit, performance, and reliability.

Radiator performance. Helps maintain proper engine cooling and function.

Transmission oil cooler included. Adds integrated cooling support in one radiator assembly.

Cross-references APDI 8012925, CSF 3349 and CSF 3637 for the same application. See all 11.

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Denso 221-0520 Radiator for Toyota Sienna

The Denso 221-0520 radiator is built for 2006 Toyota Sienna applications without the tow package, from 9/05. It is engineered to support stable engine temperatures with OE-style fitment and cooling performance for daily driving and demanding conditions.

Key Features

  • Core dimensions: 18.8120 in. height, 26.5620 in. width, and 0.8750 in. thickness
  • Transmission oil cooler included for integrated cooling support
  • Inlet diameter: 0.9370 in.; outlet diameter: 1.5620 in.
  • Built to Denso OE standards for configuration, materials, and fitment
  • Designed for 2006 Toyota Sienna, w/o tow package (from 9/05)

Detailed Description

Denso part number 221-0520 is a replacement radiator for the 2006 Toyota Sienna, w/o tow package (from 9/05). Denso supplies radiators to OE vehicle manufacturers worldwide, and this radiator reflects that OE-focused engineering with matched tank design, fin pitch, core sizing, and material selection. The result is a radiator that supports consistent coolant flow and heat transfer while maintaining the fitment expected for the Toyota Sienna platform.

This radiator includes a transmission oil cooler, making it a practical choice for vehicles that rely on integrated fluid temperature management. If you are replacing a leaking, clogged, or damaged radiator on a 2006 Toyota Sienna, part number 221-0520 provides a direct-fit cooling solution built around the original application.

This part cross-references Spectra Premium (e.g., CU2925) for the same application.

What This Radiator Helps Address

  • Engine overheating caused by reduced coolant flow or internal blockage
  • Coolant leaks from a cracked or corroded radiator core or tank
  • Transmission temperature concerns when the integrated cooler is part of the system
  • Cooling performance loss from worn or damaged OE radiator components
  • Fitment issues when replacing the original radiator on a 2006 Toyota Sienna

Installation Notes and Tips

Verify vehicle configuration before installation: this radiator is for the 2006 Toyota Sienna without the tow package, from 9/05. Confirm inlet and outlet hose sizes, transmission cooler line routing, and mounting points against the original unit before removal. Flush the cooling system, inspect hoses and clamps, and replace any worn seals or related components during service.

Quality Assurance

Denso radiators are produced to OE-level standards and undergo durability and function testing to help ensure reliable cooling performance and proper fitment. Part number 221-0520 is built to meet the demands of everyday operation while maintaining the configuration expected for the Toyota Sienna application.

This part fits 1 vehicle
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelPositionNotes
2006ToyotaSiennaN/Aw/o Tow Package (From 9/05)
Directly replaces or cross-references 11 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012925CSF — 3349CSF — 3637DPI Performance Racing Products — 2925OSC — 2925Reach Cooling — 41-2925Spectra Premium — CU2925Toyota — 16041-0A380Toyota — 16410-YZZAWTYC Cooling - Archived — 2925Vista Pro — 433861