Denso 221-3121 Radiator

Brand Denso 221-3121
Core Height 15.8120
Core Thickness 0.6250
Core Width 29.4370
Inlet Diameter 1.3750
Outlet Diameter 1.5620
Transmission Oil Cooler Included YES
Fits Lexus · 11 vehicles

OE experience. Built to meet strict OE standards for reliable performance and fit.

Radiator performance. Helps maintain proper engine cooling and function.

Transmission oil cooler included. Adds integrated cooling support in one radiator assembly.

Cross-references APDI 8012222, CSF 2606 and DPI Performance Racing Products 2222 for the same application. See all 9.

$159.79Free shipping
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Order total $159.79
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Free returns within 60 days if it doesn't fit when fitment is verified.

Denso Radiator for Lexus GS300 and GS400

Denso 221-3121 is a direct-fit radiator for select Lexus GS300 and GS400 applications. Built to OE specifications for core size, tank design, fin pitch, and materials, it supports stable engine temperature control and consistent cooling performance.

Key Features

  • Core height: 15.8120 in.
  • Core width: 29.4370 in.
  • Core thickness: 0.6250 in.
  • Transmission oil cooler included for automatic transmission applications
  • Inlet diameter: 1.3750 in.
  • Outlet diameter: 1.5620 in.
  • OE-style fitment for Lexus GS300 and Lexus GS400

Detailed Description

This Denso radiator, part number 221-3121, is engineered for 1998-2005 Lexus GS300 and 1998-2000 Lexus GS400 models. Denso supplies radiators to OE vehicle manufacturers worldwide, and this unit reflects that experience with dimensions and construction selected to match factory cooling system requirements. The radiator includes a transmission oil cooler and is built to support reliable heat transfer in daily driving and demanding conditions. This part cross-references Spectra Premium CU2222 and CSF 2606 for the same application.

What This Radiator Helps Address

  • Engine overheating from a restricted or leaking radiator
  • Coolant loss caused by cracked tanks or damaged core tubes
  • Poor heat rejection from an aging cooling system
  • Transmission fluid temperature control concerns in equipped vehicles
  • Fitment issues when replacing an OE-style Lexus GS300 or GS400 radiator

Installation Notes and Tips

Verify inlet and outlet hose sizes, mounting points, and transmission cooler line connections before installation. Flush the cooling system, inspect hoses and clamps, and refill with the correct coolant mixture after the radiator is installed. Confirm that the radiator cap, thermostat, and cooling fans are functioning properly to protect the new unit and maintain stable operating temperature.

Quality Assurance

Denso radiators are manufactured to meet OE standards for configuration, durability, and function. Each radiator is tested for performance and reliability before release, supporting consistent cooling performance in Lexus GS300 and Lexus GS400 applications.

This part fits 11 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelPositionNotes
2005LexusGS300N/A—
2004LexusGS300N/A—
2003LexusGS300N/A—
2002LexusGS300N/A—
2001LexusGS300N/A—
2000LexusGS300N/A—
2000LexusGS400N/A—
1999LexusGS300N/A—
1999LexusGS400N/A—
1998LexusGS300N/A—
1998LexusGS400N/A—
Directly replaces or cross-references 9 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012222CSF — 2606DPI Performance Racing Products — 2222Lexus — 16400-46570OSC — 2222Reach Cooling — 41-2222Spectra Premium — CU2222TYC Cooling - Archived — 2222Vista Pro — 431465