Denso 221-3166 Radiator

Denso 221-3166 Radiator for Lexus RX300

The Denso 221-3166 radiator is an OE-style cooling replacement built for 2001-2003 Lexus RX300 models with a 16mm core. It is engineered to match factory dimensions and cooling requirements for dependable engine temperature control and consistent fitment.

Key Features

• Direct-fit radiator for 2001-2003 Lexus RX300, N/A position
• Core dimensions: 17.6870 in. height, 29.0620 in. width, 0.6250 in. thickness
• 1.3750 in. inlet and 1.3750 in. outlet diameters
• Transmission oil cooler included
• Built to OE configuration standards for tanks, fin pitch, core size, and materials
• Part number 221-3166 for streamlined catalog lookup

Detailed Description

Denso radiator 221-3166 is designed for the 2001-2003 Lexus RX300 and follows OE supplier specifications for cooling performance, fitment, and durability. Denso uses factory-style radiator configurations and materials to help maintain proper coolant flow and heat transfer, while the integrated transmission oil cooler supports vehicles equipped with automatic transmission cooling through the radiator assembly. This radiator is a practical replacement for Lexus RX300 owners seeking a factory-matched cooling component with verified dimensions and connection sizes.

This part cross-references Spectra Premium CU2272 and CSF 2804 for the same application.

What It Helps Address

• Engine overheating caused by a leaking or restricted radiator
• Coolant loss from cracked tanks or damaged core passages
• Transmission fluid temperature concerns when the radiator cooler circuit is compromised
• Poor heat dissipation from an aging or clogged cooling assembly
• Fitment issues from non-OE replacement dimensions

Installation Notes and Tips

Verify the vehicle is a 2001-2003 Lexus RX300 with a 16mm core before ordering. Confirm inlet and outlet hose sizes, transmission cooler line routing, and mounting points against the original radiator. Flush the cooling system, inspect hoses and clamps, and refill with the correct coolant mixture after installation. Bleed air from the system according to factory service procedures to help prevent hot spots and temperature fluctuations.

Quality Assurance

Denso supplies radiators to OE vehicle manufacturers worldwide, and this radiator is built to meet rigid factory standards for configuration, durability, and function. Each unit is tested for performance and reliability to support consistent cooling under demanding driving conditions.