Denso 221-3169 Radiator

Brand Denso 221-3169
Core Height 14.7500
Core Thickness 0.6250
Core Width 27.9370
Inlet Diameter 1.5000
Outlet Diameter 1.5000
Transmission Oil Cooler Included NO
Fits Lexus · 20 vehicles

OE experience. Built with OE-level know-how for reliable performance and fit.

Strictly tested. Passes durability and function tests for dependable cooling.

Radiator performance. Helps maintain proper engine cooling and function.

Cross-references APDI 8012968, CSF 3295 and DPI Performance Racing Products 2968 for the same application. See all 9.

$138.25Free shipping
In stock · usually ships same day before 1pm CST
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Step 2 — Quantity
Order total $138.25
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Free returns within 60 days if it doesn't fit when fitment is verified.

Denso Radiator for Lexus IS350 and IS250

The Denso 221-3169 radiator is built for direct-fit cooling performance in select Lexus applications. It is engineered to match OE-style dimensions and materials, with core sizing and tank configuration that support proper engine temperature control in daily driving and demanding conditions.

  • Core height: 14.7500 in.
  • Core width: 27.9370 in.
  • Core thickness: 0.6250 in.
  • Inlet diameter: 1.5000 in.
  • Outlet diameter: 1.5000 in.
  • No transmission oil cooler included
  • OE-focused radiator design from Denso

OE-Style Cooling Performance

Denso uses OE supplier experience to build radiators that follow strict fitment and durability standards. The 221-3169 radiator is made for 2006-2015 Lexus IS350 and 2006-2013 Lexus IS250 applications, with dimensions and construction intended to support consistent coolant flow and heat rejection. If you are replacing a leaking or restricted radiator on a Lexus IS350 or Lexus IS250, this part number 221-3169 provides a direct replacement path.

This part cross-references Lexus (e.g., 16400-31440) for the same application.

Common Reasons to Replace the Radiator

  • Coolant leaks from a cracked or corroded radiator
  • Engine temperature running higher than normal
  • Restricted coolant flow from internal buildup
  • Damaged inlet or outlet connections
  • Cooling system service on a Lexus IS350 or Lexus IS250

Installation Notes and Tips

Verify core dimensions, inlet and outlet size, and transmission cooler requirements before installation. This radiator does not include a transmission oil cooler, so confirm your vehicle’s cooling system configuration matches the part. Replace coolant with the correct specification, inspect hoses and clamps, and bleed air from the system after installation to help restore stable operating temperature.

Quality Assurance

Denso radiators are built to OE standards and undergo durability and function testing before release. That manufacturing approach supports reliable fitment and cooling performance for Lexus IS350 and Lexus IS250 radiator replacement applications.

This part fits 20 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelSubmodelPositionNotes
2015LexusIS350CN/A—
2015LexusIS350C F SportN/A—
2014LexusIS350CN/A—
2014LexusIS350C F SportN/A—
2013LexusIS250—N/A—
2013LexusIS350—N/A—
2012LexusIS250—N/A—
2012LexusIS350—N/A—
2011LexusIS250—N/A—
2011LexusIS350—N/A—
2010LexusIS250—N/A—
2010LexusIS350—N/A—
2009LexusIS250—N/A—
2009LexusIS350—N/A—
2008LexusIS250—N/A—
2008LexusIS350—N/A—
2007LexusIS250—N/A—
2007LexusIS350—N/A—
2006LexusIS250—N/A—
2006LexusIS350—N/A—
Directly replaces or cross-references 9 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012968CSF — 3295DPI Performance Racing Products — 2968Lexus — 16400-31440OSC — 2968Reach Cooling — 41-2968Spectra Premium — CU2968TYC Cooling - Archived — 2968Vista Pro — 434053