Denso 221-4100 Radiator
OE Quality 60-Day Returns
Denso

Denso 221-4100 Radiator

Brand Denso 221-4100
Core Height 16.8120
Core Thickness 1.0000
Core Width 29.4370
Inlet Diameter 1.5620
Outlet Diameter 1.5000
Transmission Oil Cooler Included YES
Fits Lexus · 6 vehicles

OE experience. Built to meet strict OE standards for fit, performance, and reliability.

Radiator performance. Helps maintain proper engine cooling and dependable function.

Transmission oil cooler included. Adds integrated cooling support in one radiator assembly.

Cross-references APDI 8012418, CSF 2806 and DPI Performance Racing Products 2419 for the same application. See all 9.

$173.67Free shipping
In stock · usually ships same day before 1pm CST
Step 1 — Confirm fitment
Free return shipping if it doesn't fit when you check fitment here first.
Select your vehicle to confirm fitment
Verify this part fits before purchasing — free returns if it doesn't
Step 2 — Quantity
Order total $173.67
Free shipping to the continental U.S.
Free returns within 60 days if it doesn't fit when fitment is verified.
Not what you need? See all Radiator options

Denso Radiator for Lexus LS430

The Denso 221-4100 radiator is built for 2001-2006 Lexus LS430 models with the tow package. It follows OE-style dimensions and materials to support consistent engine cooling, proper fitment, and dependable transmission fluid temperature control through the integrated cooler.

  • Fits 2001-2006 Lexus LS430, w/ Tow Package
  • Core height: 16.8120 in.
  • Core width: 29.4370 in.
  • Core thickness: 1.0000 in.
  • Inlet diameter: 1.5620 in.
  • Outlet diameter: 1.5000 in.
  • Transmission oil cooler included

OE-Style Cooling Performance

Denso 221-4100 is engineered from the company’s OE radiator experience, with configurations, tank design, fin pitch, core dimensions, and materials selected to match manufacturer standards. For Lexus LS430 applications, that means a radiator built to support stable coolant flow, efficient heat transfer, and reliable operation under demanding driving conditions. This part cross-references Lexus 16400-50251 for the same application.

Common Issues This Radiator Can Address

  • Overheating caused by a worn or inefficient radiator
  • Coolant temperature instability during heavy driving or towing
  • Transmission fluid heat buildup when the cooler circuit is part of the radiator
  • Leaks from aging radiator tanks or core deterioration
  • Reduced cooling efficiency from clogged or damaged internal passages

Installation Notes and Tips

Verify the vehicle is a 2001-2006 Lexus LS430 with the tow package before ordering. Compare inlet and outlet sizes, core dimensions, and cooler connections to the original unit before installation. Flush the cooling system, inspect hoses and clamps, and refill with the correct coolant mixture after installation. Confirm there are no leaks and that engine temperature remains stable during a road test.

Quality Assurance

Denso radiators are backed by the brand’s OE supply experience and are subjected to durability and function testing before release. The 221-4100 is built to meet OE manufacturer standards for fitment and performance in the Lexus LS430 cooling system.

Related reading

This part fits 6 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelPositionNotes
2006LexusLS430N/Aw/ Tow Package
2005LexusLS430N/Aw/ Tow Package
2004LexusLS430N/Aw/ Tow Package
2003LexusLS430N/Aw/ Tow Package
2002LexusLS430N/Aw/ Tow Package
2001LexusLS430N/Aw/ Tow Package
Directly replaces or cross-references 9 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012418CSF — 2806DPI Performance Racing Products — 2419Lexus — 16400-50251OSC — 2419Reach Cooling — 41-2419Spectra Premium — CU2419TYC Cooling - Archived — 2418Vista Pro — 432454