Denso 221-4408 Radiator

Brand Denso 221-4408
Core Height 17.6870
Core Thickness 1.0000
Core Width 25.3750
Inlet Diameter 1.3750
Outlet Diameter 1.3750
Transmission Oil Cooler Included YES
Fits Nissan · 4 vehicles

OE experience. Built to OE standards for reliable performance and fit.

Radiator performance. Helps maintain proper engine cooling and function.

Transmission oil cooler included. Adds integrated cooling support in one assembly.

Cross-references APDI 8012259, CSF 3133 and Datsun/Nissan 21460-7B000 for the same application. See all 10.

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Denso Radiator for Nissan Quest

The Denso 221-4408 radiator is built for 1999-2002 Nissan Quest applications and follows OE-style dimensions and materials for proper cooling system fitment. With a transmission oil cooler included and matched inlet and outlet sizes, it supports direct replacement needs for Quest owners looking for a radiator that aligns with factory specifications.

Key Features

  • Fits 1999-2002 Nissan Quest
  • Part number: 221-4408
  • Core height: 17.6870 in.
  • Core width: 25.3750 in.
  • Core thickness: 1.0000 in.
  • Inlet diameter: 1.3750 in.
  • Outlet diameter: 1.3750 in.
  • Transmission oil cooler included

Detailed Description

Denso 221-4408 is a replacement radiator engineered around OE requirements for cooling performance, fitment, and durability. Denso supplies radiators to original equipment vehicle manufacturers worldwide, and this radiator reflects that experience through its core dimensions, tank configuration, fin pitch, and material selection. For a Nissan Quest radiator replacement, the 221-4408 provides the dimensions and integrated transmission oil cooler needed for a factory-style service part.

This radiator cross-references APDI 8012259 for the same application. It also aligns with other aftermarket listings for the 1999-2002 Nissan Quest, including CSF 3133 and Spectra Premium CU2259.

Common Problems This Radiator Can Address

  • Engine overheating caused by a leaking or restricted radiator
  • Coolant loss from cracked tanks or damaged core passages
  • Poor heat transfer from an aging radiator core
  • Transmission cooling concerns when the radiator cooler circuit is compromised
  • Fitment issues from using a radiator that does not match OE dimensions

Installation Notes and Tips

Verify core height, core width, thickness, inlet diameter, and outlet diameter before installation. Confirm that the transmission cooler line connections match the vehicle setup on your 1999-2002 Nissan Quest. Flush the cooling system, inspect hoses and clamps, and replace worn seals or related components during radiator service to help maintain proper cooling performance.

Quality Assurance

Denso radiators are built to meet OE manufacturer standards and are tested for durability and function before release. The 221-4408 is designed to deliver reliable cooling performance under demanding operating conditions while maintaining the fitment expected from an OE-style replacement radiator.

This part fits 4 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelPositionNotes
2002NissanQuestN/A—
2001NissanQuestN/A—
2000NissanQuestN/A—
1999NissanQuestN/A—
Directly replaces or cross-references 10 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8012259CSF — 3133Datsun/Nissan — 21460-7B000DPI Performance Racing Products — 2259Mercury — XF5Z 8005-AAOSC — 2259Reach Cooling — 41-2259Spectra Premium — CU2259TYC Cooling - Archived — 2259Vista Pro — 431392