Denso 221-9252 Radiator
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Denso

Denso 221-9252 Radiator

Brand Denso 221-9252
Core Height 25.2000
Core Thickness 1.5700
Core Width 17.9900
Inlet Diameter 1.8000
Outlet Diameter 1.8000
Transmission Oil Cooler Included YES
Fits Mercedes-Benz · 41 vehicles

OE experience. Built to meet rigid OE standards for fit, performance, and reliability.

Radiator performance. Helps maintain proper engine cooling and function.

Durability tested. Passed strict function and durability checks for dependable service.

Cross-references APDI 8013162, CSF 3548 and DPI Performance Racing Products 13162 for the same application. See all 13.

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Denso Radiator for Mercedes-Benz Cooling

The Denso 221-9252 radiator is built for direct-fit engine cooling performance in select Mercedes-Benz applications. It combines OE-style dimensions with an integrated transmission oil cooler and the inlet and outlet sizing needed for proper coolant flow.

  • OE-style radiator construction from Denso
  • Core height: 25.2000
  • Core width: 17.9900
  • Core thickness: 1.5700
  • Transmission oil cooler included: yes
  • Inlet diameter: 1.8000
  • Outlet diameter: 1.8000

Fitment and Application Details

Fits 2015-2017 Mercedes-Benz CLS550, N/A, Primary (Engine Cooling). Fits 2015-2017 Mercedes-Benz E400, N/A, Primary. Fits 2015-2017 Mercedes-Benz E550, N/A, Primary (Engine Cooling). Fits 2015-2016 Mercedes-Benz CLS400, N/A, Primary. Fits 2012-2016 Mercedes-Benz E350, N/A, Exc. PZEV Spec. Fits 2012-2015 Mercedes-Benz C350, N/A, Exc. PZEV Spec. Fits 2013-2015 Mercedes-Benz E400, N/A, Exc. PZEV Spec. Fits 2013-2015 Mercedes-Benz GLK350, N/A, Exc. PZEV Spec. Fits 2013-2014 Mercedes-Benz C300, N/A, Exc. PZEV Spec. Fits 2012-2014 Mercedes-Benz CLS550, N/A. Fits 2012-2014 Mercedes-Benz E550, N/A, Primary(Engine Cooling). Fits 2011-2013 Mercedes-Benz E350, N/A. Fits 2013 Mercedes-Benz GLK250, N/A, To 09/02/2012. Fits 2010-2011 Mercedes-Benz E550, N/A. Fits 2010 Mercedes-Benz E350, N/A, Exc. PZEV Spec (To 10/06/2009).

What This Radiator Helps Address

  • Overheating caused by a leaking or restricted radiator
  • Coolant loss from cracked tanks or damaged core passages
  • Transmission temperature concerns when the cooler circuit is part of the radiator
  • Poor heat transfer from a worn or corroded factory unit
  • Fitment issues when replacing the original Mercedes-Benz radiator

Installation Notes and Tips

Verify the vehicle’s engine and emissions configuration before ordering, especially for PZEV and non-PZEV applications. Confirm radiator dimensions, inlet and outlet size, and transmission cooler connections against the original unit before installation. For Mercedes-Benz E350, E400, E550, CLS400, CLS550, C300, C350, GLK250, and GLK350 applications, match the exact year and notes shown in the fitment list.

Quality Assurance

Denso supplies radiators to OE car makers worldwide, and this part is built to OE-level standards for configuration, tank design, fin pitch, core dimensions, and materials. Each radiator is tested for durability and function to support reliable cooling performance under demanding driving conditions. This part cross-references Spectra Premium CU13162 and CSF 3548 for the same application.

Related reading

This part fits 41 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelBody TypePositionNotes
2017Mercedes-BenzCLS550—N/APrimary (Engine Cooling)
2017Mercedes-BenzE400CoupeN/APrimary
2017Mercedes-BenzE550—N/APrimary (Engine Cooling)
2016Mercedes-BenzCLS400—N/APrimary
2016Mercedes-BenzCLS550—N/APrimary (Engine Cooling)
2016Mercedes-BenzE350—N/AExc. PZEV Spec
2016Mercedes-BenzE400—N/APrimary
2016Mercedes-BenzE550—N/APrimary (Engine Cooling)
2015Mercedes-BenzC350—N/AExc. PZEV Spec
2015Mercedes-BenzCLS400—N/APrimary
2015Mercedes-BenzCLS550—N/APrimary (Engine Cooling)
2015Mercedes-BenzE350—N/AExc. PZEV Spec
2015Mercedes-BenzE400—N/AExc. PZEV Spec
2015Mercedes-BenzE400—N/APrimary
2015Mercedes-BenzE550—N/APrimary (Engine Cooling)
2015Mercedes-BenzGLK350—N/AExc. PZEV Spec
2014Mercedes-BenzC300—N/AExc. PZEV Spec
2014Mercedes-BenzC350—N/AExc. PZEV Spec
2014Mercedes-BenzCLS550—N/A—
2014Mercedes-BenzE350—N/AExc. PZEV Spec
2014Mercedes-BenzE400—N/AExc. PZEV Spec
2014Mercedes-BenzE550—N/APrimary(Engine Cooling)
2014Mercedes-BenzGLK350—N/AExc. PZEV Spec
2013Mercedes-BenzC300—N/AExc. PZEV Spec
2013Mercedes-BenzC350—N/AExc. PZEV Spec
2013Mercedes-BenzCLS550—N/A—
2013Mercedes-BenzE350—N/AExc. PZEV Spec
2013Mercedes-BenzE350—N/A—
2013Mercedes-BenzE400—N/AExc. PZEV Spec
2013Mercedes-BenzE550—N/APrimary(Engine Cooling)
2013Mercedes-BenzGLK250—N/ATo 09/02/2012
2013Mercedes-BenzGLK350—N/AExc. PZEV Spec
2012Mercedes-BenzC350—N/AExc. PZEV Spec
2012Mercedes-BenzCLS550—N/A—
2012Mercedes-BenzE350—N/AExc. PZEV Spec
2012Mercedes-BenzE350—N/A—
2012Mercedes-BenzE550—N/APrimary(Engine Cooling)
2011Mercedes-BenzE350—N/A—
2011Mercedes-BenzE550—N/A—
2010Mercedes-BenzE350—N/AExc. PZEV Spec (To 10/06/2009)
2010Mercedes-BenzE550—N/A—
Directly replaces or cross-references 13 part numbers
Cross-reference numbers are provided for identification purposes only. Always confirm fitment before ordering.
APDI — 8013162CSF — 3548DPI Performance Racing Products — 13162Mercedes-Benz — 995002703Mercedes-Benz — 0995002703Mercedes-Benz — 995006203Mercedes-Benz — 0995006203Mercedes-Benz — 2045001203Mercedes-Benz — 2045003603OSC — 13162Reach Cooling — 41-13162Spectra Premium — CU13162TYC Cooling - Archived — 13498