Genuine 6421420080 Exhaust Manifold Gasket

Brand Genuine 6421420080
Fits Mercedes-Benz, Freightliner, and Dodge · 28 vehicles

OE direct replacement. Exhaust manifold gasket for a precise sealing fit.

Seals the exhaust manifold to help maintain exhaust system integrity.

$18.77Free shipping
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Exhaust Manifold Gasket for Mercedes-Benz and Sprinter

Genuine part number 6421420080 is an exhaust manifold gasket for the manifold-to-crank case sealing point. It is listed for select Mercedes-Benz E350, GL350, ML350, S350, R350, and Sprinter applications, as well as Dodge Sprinter 2500 and 3500 models.

Key Features

  • Genuine exhaust manifold gasket, part number 6421420080
  • Seals the manifold to crank case interface
  • Direct fitment for select 2007-2013 Mercedes-Benz and Dodge Sprinter diesel applications
  • Supports exhaust system sealing at a critical engine connection
  • Compatible with E350, GL350, ML350, S350, R350, Sprinter 2500, and Sprinter 3500 listings

Detailed Description

This Genuine exhaust manifold gasket, 6421420080, is specified for manifold-to-crank case sealing on select Mercedes-Benz and Dodge Sprinter vehicles. It is used at the exhaust manifold connection point to help maintain a proper seal between engine components and the exhaust path. For buyers searching for a Mercedes-Benz E350 exhaust manifold gasket or a Sprinter 2500 manifold to crank case gasket, this part number provides a direct-reference option for the listed applications.

Fitment includes 2011-2013 Mercedes-Benz E350, 2010-2013 Mercedes-Benz GL350, 2010-2013 Mercedes-Benz ML350, 2012-2013 Mercedes-Benz S350, 2010-2012 Mercedes-Benz R350, 2010-2012 Mercedes-Benz Sprinter 2500, 2010-2012 Mercedes-Benz Sprinter 3500, 2007-2009 Dodge Sprinter 2500, and 2007-2009 Dodge Sprinter 3500. This part number, 6421420080, is a practical match for shoppers comparing OE-style exhaust sealing components for these diesel platforms.

Common Issues This Part Addresses

  • Exhaust leakage at the manifold-to-crank case sealing surface
  • Noise from a compromised exhaust seal
  • Soot or residue around the manifold connection
  • Loss of sealing integrity after manifold service
  • Replacement during exhaust manifold repair on Mercedes-Benz and Sprinter models

Installation Notes and Tips

Confirm the vehicle year, make, and model against the listed fitment before installation. Clean the mating surfaces thoroughly and inspect the manifold and crank case sealing faces for damage or warpage before installing the new gasket. Use the exact application notes for your vehicle, since this part is listed specifically for the manifold-to-crank case location.

Quality Assurance

Genuine OEM-style replacement part identified by part number 6421420080 for the listed Mercedes-Benz and Dodge Sprinter applications.

This part fits 28 vehicles
Always verify fitment with your vehicle's VIN if unsure. Submodel & trim restrictions may apply.
YearMakeModelFuel TypePositionNotes
2013Mercedes-BenzE350DIESELN/AManifold to Crank Case
2013Mercedes-BenzGL350—N/AManifold to Crank Case
2013Mercedes-BenzML350DIESELN/AManifold to Crank Case
2013Mercedes-BenzS350—N/AManifold to Crank Case
2012Mercedes-BenzE350DIESELN/AManifold to Crank Case
2012Mercedes-BenzGL350—N/AManifold to Crank Case
2012Mercedes-BenzML350DIESELN/AManifold to Crank Case
2012Mercedes-BenzR350DIESELN/AManifold to Crank Case
2012Mercedes-BenzS350—N/AManifold to Crank Case
2012Mercedes-BenzSprinter 2500—N/AManifold to Crank Case
2012Mercedes-BenzSprinter 3500—N/AManifold to Crank Case
2011Mercedes-BenzE350DIESELN/AManifold to Crank Case
2011Mercedes-BenzGL350—N/AManifold to Crank Case
2011Mercedes-BenzML350DIESELN/AManifold to Crank Case
2011Mercedes-BenzR350DIESELN/AManifold to Crank Case
2011Mercedes-BenzSprinter 2500—N/AManifold to Crank Case
2011Mercedes-BenzSprinter 3500—N/AManifold to Crank Case
2010Mercedes-BenzGL350—N/AManifold to Crank Case
2010Mercedes-BenzML350DIESELN/AManifold to Crank Case
2010Mercedes-BenzR350DIESELN/AManifold to Crank Case
2010Mercedes-BenzSprinter 2500—N/AManifold to Crank Case
2010Mercedes-BenzSprinter 3500—N/AManifold to Crank Case
2009DodgeSprinter 2500—N/AManifold to Crank Case
2009DodgeSprinter 3500—N/AManifold to Crank Case
2008DodgeSprinter 2500—N/AManifold to Crank Case
2008DodgeSprinter 3500—N/AManifold to Crank Case
2007DodgeSprinter 2500—N/AManifold to Crank Case
2007DodgeSprinter 3500—N/AManifold to Crank Case